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by Dr. Peter J. Bridge PhD

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Author: Dr. Peter J. Bridge PhD
ISBN: 0801857449
Language: English
Pages: 248 pages
Category: Medicine
Publisher: The Johns Hopkins University Press; 2nd edition (October 6, 1997)
Rating: 4.6
Formats: azw mbr mobi lrf
FB2 size: 1503 kb | EPUB size: 1353 kb | DJVU size: 1617 kb

Calculation of Genetic Risks : Worked Examples in DNA Diagnostics .

The Calculation of Genetic Risks : Worked Examples in DNA Diagnostics. By (author) Peter J. Bridge. The book begins with the general theory of estimating genetic risks, then progresses through familial and isolated cases, both simple and complex. Worked examples are provided throughout the text.

Start by marking The Calculation Of Genetic Risks: Worked Examples . It will be the basic aim of this book," writes Peter J. Bridge, "to impart to the reader the fundamentals of how we start with laboratory results and end up with numbers representing genetic risks.

Start by marking The Calculation Of Genetic Risks: Worked Examples In Dna Diagnostics as Want to Read: Want to Read savin. ant to Read.

Baltimore: Johns Hopkins University Press. Authors and Affiliations. 1. Pamela L. Flodman.

Authors and affiliations. Baltimore: Johns Hopkins University Press. 2. Y State Psychiatric Institute, Columbia UniversityNew York.

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Similar books and articles. Introduction to Risk Calculation in Genetic Counselling. Learning From Worked-Out Examples: The Effects of Example Variability and Elicited Self-Explanations. I. H. Ellis - 1993 - Journal of Medical Ethics 19 (1):56-57. The New Genetic Diagnostics Law. Implications for the Consultation of Pregnant to Antenatal Diagnostics. Robin Stark, Alexander Renkl, Hans Gruber & Heinz Mandl - unknown. Genetic Information in the Age of Genohype. Péter Kakuk - 2006 - Medicine, Health Care and Philosophy 9 (3):325-337.

In most of this book we have been concerned with a discussion of the basic properties of a plasma and have referred to experimental results only in passing, without giving details of how they are obtained. Here we redress the balance somewhat by discussing diagnostic techniques, that is the methods which are used to obtain information about actual plasmas. Since many plasmas of interest are under.

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The Calculation of Genetic Risks: Worked Examples in DNA Diagnostics. Spontaneous mutation provides the substrate for evolution on one hand and for genetic susceptibility to disease on the other hand

The Calculation of Genetic Risks: Worked Examples in DNA Diagnostics. Spontaneous mutation provides the substrate for evolution on one hand and for genetic susceptibility to disease on the other hand.

Booklist: 1. Bridge PJ. The Calculation of Genetic Risk. Worked examples in DNA diagnostics. Teaching methods: Lectures with vast range of examples of genetic diagnostic methods and human genetic diseases. 1997, The Johns Hopkins Press. RULES AND REGULATIONS 1. General rules:  seminars are obligatory,  students presence at seminars is registered,  the scope of knowledge required for each seminar is given on Department’s information board,  students are expected to read the appropriate passages from textbooks 2. Form and conditions of course completion:  written test covering topics of seminars,  the test consists of 50 questions.

"It will be the basic aim of this book," writes Peter J. Bridge, "to impart to the reader the fundamentals of how we start with laboratory results and end up with numbers representing genetic risks." This practical guide for both clinical and research geneticists explains how to calculate an individual's genetic risk based on information available from genetic testing and from family pedigrees. Bridge begins with the general theory of estimating genetic risks, then progresses through familial and isolated cases, both simple and complex. A major strength of the book lies in the wealth of worked examples provided throughout the text. The disorders are selected to be widely applicable or adaptable as needed.

New to this edition are sections on consanguinity, multipoint linkage analysis, nonparametric methods, homozygosity mapping, and physical mapping. Also new is a chapter on other DNA-based calculations, including sections on paternity, zygosity, family reconstructions, and quantification of mitochondrial mutations.

From reviews of the first edition: "To use a computer package intelligently and safely, you need to have in reserve the ability to do the calculation by hand, at least approximately, so as to appreciate which factors contribute to the risk. And the current computer packages cannot cope with several factors which can crucially affect the final risk, such as germinal mosaicism or the risk of maternal cell contamination... Bridge's book is very thorough. Every combination of pedigree structure and marker data is discussed, with numerous tables showing the result of systematically varying one or more parameters." -- Journal of Medical Genetics

"A useful reference book." -- American Journal of Human Genetics